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21550 Angela Lane
Venice, FL 34293

Zyderm® & Zyplast® are injectable collagen dermal fillers made of a highly purified bovine collagen suspended in a saline solution.  Zyderm® & Zyplast® are used in Collagen Replacement Therapy treatments, aimed to replace the natural collagen that is lost from the skin due to aging. Because bovine collagen is a foreign protein for humans, a skin patch test is required before treatment to ensure that the patient does not have an allergic reaction to the ingredients in the filler.

Zyderm® and Zyplast® come in different formulas, each used to treat different severities of skin defects:

Zyderm® I is comprised of 25% bovine collagen, and 0.3% lidocaine. It is used to treat superficial skin defects, such as fine lines, wrinkles, and shallow scars. This dermal filler formula lasts between 6 weeks to 3 months.

Zyderm® II is comprised of 50% bovine collagen, and 0.3% lidocaine and is generally used on more moderate scarring and wrinkles. This dermal filler formula lasts between 4 to 5 months.

Zyplast® has a denser composition, and is used for deep lines and wrinkles, lip enhancement and acne scars. Zyplast® generally lasts 9 months to 1 year.

Results can be seen immediately after injection. Follow-up maintenance treatments are required since the collagen injections eventually biodegrade. Side effects are generally mild and can include swelling, redness and bruising. These usually resolve after 1 or 2 days and within 1 week after injection in the lips.


The safety of our employees, their families and patients impacted by Hurricane Ian continues to be our primary concern, and our thoughts and prayers remain with everyone affected by the storm.

Our Coast Venice office will be closed tomorrow 10/6.